Table 1.
Comparison of Demographics and Baseline Clinical Characteristics by Frailty Status
| Short Physical Performance Battery |
Fried Frailty Phenotype |
|||||
|---|---|---|---|---|---|---|
| Frail | Not Frail | P Value | Frail | Not Frail | P Value | |
| No. of subjects | 26 | 236 | 99 | 255 | ||
| Age, yr | 59 (50–65) | 59 (50–65) | 0.86 | 58 (46–63) | 59 (50–65) | 0.11 |
| Male | 13 (50%) | 135 (57%) | 0.48 | 50 (51%) | 142 (56%) | 0.38 |
| Female | 13 (50%) | 101 (43%) | 49 (49%) | 113 (44%) | ||
| Race/ethnicity | ||||||
| White, non-Hispanic | 15 (58%) | 180 (76%) | 0.07 | 65 (66%) | 210 (82%) | 0.003 |
| Black | 5 (19%) | 13 (6%) | 5 (5%) | 8 (3%) | ||
| Asian | 1 (4%) | 15 (6%) | 7 (7%) | 8 (3%) | ||
| Hispanic | 2 (8%) | 19 (8%) | 7 (7%) | 13 (5%) | ||
| Other | 1 (4%) | 4 (2%) | 14 (14%) | 11 (4%) | ||
| Diagnostic category* | ||||||
| Group A (COPD) | 6 (23%) | 78 (33%) | 0.38 | 25 (25%) | 70 (27%) | 0.85 |
| Group B (PAH) | 2 (8%) | 14 (6%) | 6 (6%) | 14 (5%) | ||
| Group C (CF) | 0 (0%) | 13 (6%) | 7 (7%) | 24 (9%) | ||
| Group D (ILD) | 18 (69%) | 131 (56%) | 61 (62%) | 147 (6%) | ||
| Body mass index, kg/m2 | 26.2 ± 7.5 | 26.1 ± 4.5 | 0.93 | 24.1 ± 4.6 | 26.0 ± 4.8 | 0.001 |
| Hemoglobin, g/dl | 12.0 ± 1.9 | 13.4 ± 2.0 | 0.004 | 12.5 ± 1.8 | 13.3 ± 2.0 | 0.001 |
| Creatinine, mg/dl | 0.9 ± 0.5 | 0.8 ± 0.2 | 0.83 | 0.8 ± 0.3 | 0.8 ± 0.2 | 0.62 |
| FEV1, L | 1.4 (1.1–1.7) | 1.3 (0.8–1.9) | 0.49 | 1.2 (0.8–1.7) | 1.3 (0.8–1.8) | 0.58 |
| FVC, L | 1.7 (1.4–2.5) | 2.2 (1.6–2.7) | 0.12 | 1.9 (1.4–2.4) | 2.0 (1.5–2.6) | 0.16 |
| 6-minute-walk distance, m | 141 (36–213) | 355 (237–485) | <0.001 | 208 (134–323) | 333 (244–423) | <0.001 |
| LAS | 78 (62–94) | 45 (36–50) | <0.001 | 44 (35–61) | 37 (33–42) | <0.001 |
Definition of abbreviations: CF = cystic fibrosis; COPD = chronic obstructive pulmonary disease; ILD = interstitial lung disease; LAS = Lung Allocation Score; PAH = pulmonary arterial hypertension.
Data are presented as n (%), mean ± SD, or median (interquartile range).
*
Diagnostic categories used for calculation of the Lung Allocation Score (9).