Table 2.
Sensitivity Analysis of NAC-associated Endpoint Risk after rs3750920, rs5743894, and rs35705950 Genotype Stratification*
| SNP (Gene) Genotype | Death/Transplant/Hosp/FVC Decline |
Death/Transplant/Hosp |
Death/Transplant/FVC Decline |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| rs3750920 (TOLLIP) CC | 3.22 (0.79–13.16) | 0.1 | 3.74 (0.35–39.80) | 0.27 | 1.27 (0.21–7.55) | 0.79 |
| rs3750920 (TOLLIP) CT | 0.76 (0.27–2.19) | 0.62 | 0.45 (0.10–2.15) | 0.32 | 0.63 (0.17–2.30) | 0.48 |
| rs3750920 (TOLLIP) TT | 0.14 (0.02–0.83) | 0.03 | † | † | 0.09 (0.01–0.76) | 0.03 |
| rs5743894 (TOLLIP) AA | 1.67 (0.71–3.95) | 0.24 | 1.43 (0.44–4.70) | 0.56 | 1.68 (0.58–4.90) | 0.34 |
| rs5743894 (TOLLIP) AG/GG | 0.33 (0.10–1.14) | 0.08 | 0.21 (0.02–1.99) | 0.18 | 0.18 (0.04–0.90) | 0.04 |
| rs35705950 (MUC5B) GG | 2.02 (0.57–7.20) | 0.28 | 1.25 (0.15–10.30) | 0.84 | 3.72 (0.69–20.16) | 0.13 |
| rs35705950 (MUC5B) GT/TT | 0.60 (0.27–1.35) | 0.22 | 0.49 (0.15–1.58) | 0.23 | 0.32 (0.11–0.94) | 0.04 |
Definition of abbreviations: CI = confidence interval; Hosp = hospitalization; HR = hazard ratio; NAC = N-acetylcysteine; SNP = single-nucleotide polymorphism.
*
Models adjusted for age, sex, FVC (percentage predicted) and diffusion capacity of the lung for carbon monoxide (percentage predicted).
†
HR cannot be estimated owing to absence of events.