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. 2015 Sep 26;4(12):891–902. doi: 10.1016/j.molmet.2015.09.005

Figure 1.

Figure 1

FXR isoform-specific gene regulation. (A) Human FXR isoforms. The different N-termini (orange in FXRα1/α2; pink in FXRα3/α4) and the MYTG insert in FXRα1/α3 are indicated. DBD, DNA-binding domain; LBD, ligand-binding domain. (B–C) FXR mRNA (B) and protein (C) levels in hepatocytes expressing each FXR variant or GFP alone (control). (D) Gene expression analysis by qRT-PCR. (E) Heatmap of gene expression profiles in hepatocytes expressing each FXR isoform or GFP (F) Bioinformatic pathway analysis of gene expression profiling. Represented are biological functions significantly associated with one or more FXR isoforms. (G) Predicted effects on hepatic metabolism for each FXR isoform. Z-score values indicate induction (orange) or repression (blue). Bars depict mean values and error bars represent SEM (n ≥ 3). *p < 0.05 vs. control. ¥p < 0.05 vs. FXRα1/α2. §p < 0.05 vs. FXRα1/α3.