Figure 6.

Systemic bioenergetic demands change Fxrα2/α1 ratios. (A–D) Hepatic Fxrα2/α1 splicing in response to metabolic stressors. Graphs represent box plots of Fxrα2/α1 ratios relative to controls upon overnight fasting and 3 h after refeeding (n = 7) (A), a single bout of intensive exercise on a treadmill for 1 h or until exhaustion (n = 6–8) (B), eight weeks of voluntary exercise in running wheels (n = 6) (C), and one week on a high fat diet (n = 5) (D). *p < 0.05 compared to control or between the indicated groups.