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. 2015 Oct 17;4(12):951–960. doi: 10.1016/j.molmet.2015.09.013

Figure 2.

Figure 2

Adult onset, liver-specific deletion of TRAF3 attenuates insulin resistance and glucose intolerance in obese mice. A–E.TRAF3f/f male mice (7 weeks) were fed a HFD for 8 weeks and infected with GFP (n = 12) or Cre (n = 11) adenoviruses via tail vein injection. A. Liver extracts were prepared 30 days after infection and immunoblotted with antibodies against TRAF3 or tubulin. B. Overnight-fasted blood glucose and insulin 25 days after infection. C. GTTs (glucose: 2 g/kg body weight) were performed 10 days after infection. D. ITTs (insulin: 1 unit/kg) 13 days after infection. E. PTTs (pyruvate: 2 g/kg) 21 days after infection. F–H.ob/ob;TRAF3f/f male mice (8–9 weeks) were infected with GFP (n = 7) or Cre (n = 8) adenoviruses via tail vein injection. F. Overnight-fasted blood glucose and insulin 8 days after infection. G. GTTs (glucose: 0.5 g/kg) were formed 16 days after infection. H. ITTs (insulin: 2 unit/kg) were performed 14 days after infection. *p < 0.05.