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. 2016 Jan 29;6:20148. doi: 10.1038/srep20148

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Copyright © 2016, Macmillan Publishers Limited

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4,753 health examination participants, who received no medication for gout and/or hyperuricemia, were analyzed. Among 3,158 male participants (left, black bars), 0, 1 and 2 nonfunctional alleles (R90H or W258X) were detected in 2,982, 174 and 2 males, respectively. Among 1,595 female participants (right, grey bars), 0, 1 and 2 nonfunctional alleles (R90H or W258X) were detected in 1,529, 63 and 3 females, respectively. Serum uric acid (SUA) levels of participants having 0, 1 and 2 nonfunctional alleles were shown in each sex. The sex-dependent effect size of SUA decrease by nonfunctional alleles (arrow) was also shown. All bars are expressed as means ± SEM.