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. 2016 Jan 29;6:20171. doi: 10.1038/srep20171

Figure 1. Effects of MMP-12 on glomerular expansion in obese mice.

Figure 1

Apo E−/− and apo E−/−MMP-12−/− mice and their heterozygote littermates (control) were fed a normal or HFD for 3, 6, and 9 months. (A) Representative photomicrographs of pathological glomerular features visualized by PAS staining. Scale bar = 20 μm. (B) Quantitative analysis of glomerular surface area expressed as a percentage of glomerular area (n = 10 glomeruli per kidney per animal). Values represent means ± SEM (n = 12 mice per group). *P < 0.05 vs. mice on normal chow; †P < 0.05 vs. mice on HFD at the same time point.