Table 1. Biochemical characteristics of apo E −/− and apo E −/− MMP12 −/− mice at different time on HFD.
| apo E−/− | apo E−/−MMP-12−/− | |||||||
|---|---|---|---|---|---|---|---|---|
| N. Chow | 3m | 6m | 9m | N. Chow | 3m | 6m | 9m | |
| Body weight (g) | 14.4 ± 0.8 | 24.7 ± 1.6* | 42.6 ± 4.3* | 68.6 ± 5.5* | 13.8 ± 0.7 | 25.8 ± 2.1* | 39.6 ± 4.8* | 62.4 ± 5.2* |
| Blood pressure (mmHg) | 125 ± 6 | 130 ± 9 | 131 ± 11 | 129 ± 12 | 121 ± 7 | 128 ± 11 | 133 ± 9 | 130 ± 9 |
| 24-h protein (mg) | 6.6 ± 1.1 | 8.3 ± 0.9 | 14.7 ± 3.1* | 27.4 ± 2.9* | 6.3 ± 0.8 | 7.5 ± 1.2 | 8.4 ± 2.3# | 11.3 ± 3.7*,# |
| Serum creatinine (mol/L) | 8.5 ± 1.7 | 10.5 ± 2.3 | 23.7 ± 3.6* | 44.2±4.8* | 8.3 ± 2.2 | 9.7 ± 0.9 | 15.6 ± 3.7*,# | 22.8 ± 3.6*,# |
| Blood glucose (mg/dL) | 105.4 ± 8.4 | 134.4 ± 10.3* | 164.2 ± 12.8* | 177.3 ± 21.6* | 117.4 ± 12.1 | 138.2 ± 13.4* | 154.7 ± 13.4* | 165.3 ± 16.4* |
| Total cholesterol (mmol/L) | 11.4 ± 1.1 | 15.6 ± 0.9 | 22.8 ± 2.7* | 25.4 ± 3.1* | 12.1 ± 0.9 | 14.5 ± 1.7 | 20.7 ± 2.1* | 23.7 ± 2.6* |
| Triglycerides (mmol/L) | 2.1 ± 0.3 | 2.4 ± 0.2 | 3.5 ± 0.4* | 3.8 ± 0.3* | 1.8 ± 0.3 | 2.2 ± 0.3 | 3.2 ± 0.2* | 3.6 ± 0.2* |
| HDL (mmol/L) | 2.2 ± 0.2 | 3.1 ± 0.3* | 3.8 ± 0.2* | 3.7 ± 0.4* | 2.4 ± 0.3 | 2.8 ± 0.3 | 3.7 ± 0.4* | 3.9 ± 0.3* |
| LDL (mmol/L) | 6.4 ± 0.4 | 8.3 ± 0.5 | 18.8 ± 1.9* | 21.6 ± 3.1* | 7.1 ± 0.4 | 8.1 ± 0.7 | 17.4 ± 2.2* | 18.4 ± 2.7* |
Values represent means ± SEM (n = 12 per group). Statistical analyses were performed by two way ANOVA with Bonferroni post hoc test, *P < 0.05 vs mice on normal chow; #P < 0.05 vs mice on HFD at the same time point.