Table 7. Finding associated with complex I under and over activity.
| Complex IUnderactivity | Complex IOveractivity | |
|---|---|---|
| Development | ||
| ASD | 44% (4/9) | 75% (3/4) |
| Regression | 63% (5/8) | 100% (4/4) |
| Loss of Language | 80% (4/5) | 75% (3/4) |
| Loss of Social Skills | 40% (2/5) | 100% (4/4) |
| Loss of Gross Motor Skills | 60% (3/5) | 0% (0/4) |
| Loss of Fine Motor Skills | 80% (4/5) | 25% (1/4) |
| Proximal Trigger | 80% (4/5) | 0% (0/4) |
| ASD Regression Typical Age | 20% (1/5) | 75% (3/4) |
| Mean (SD) Age at Regression | 63 m (29 m) | 27 m (16 m) |
| Multiple Regressions | 60% (3/5) | 25% (1/4) |
| Gene Deletion | ||
| TRMU | 38% (3/8) | 0% (0/3) |
| SCO2/TYMP/CPT1B | 88% (7/8) | 100% (3/3) |
| SHANK3 | 100% (8/8) | 66% (2/3) |
| Gastrointestinal problems | ||
| Vomiting1 | 0% (0/8) | 0% (0/4) |
| Gastroesophageal Reflux1 | 43% (3/7) | 25% (1/4) |
| Diarrhea1 | 33% (3/9) | 50% (2/4) |
| Constipation1 | 88% (7/8) | 25% (1/4) |
| Abdominal pain1 | 50% (3/6) | 0% (0/4) |
| Feeding Problems1 | 56% (5/9) | 50% (2/4) |
| Growth Problems | ||
| Failure to Thrive2 | 44% (4/9) | 25% (1/4) |
| Short Stature2 | 44% (4/9) | 0% (0/4) |
| Tall Stature2 | 22% (2/9) | 25% (1/4) |
| Obese2 | 22% (2/9) | 0% (0/4) |
| Microcephaly2 | 22% (2/9) | 0% (0/4) |
| Macrocephaly2 | 22% (2/9) | 25% (1/4) |
| Constitutional | ||
| Heat Intolerance2 | 89% (8/9) | 75% (3/4) |
| Lack of Sweating2 | 67% (6/9) | 50% (2/4) |
| Exercise Intolerance2 | 63% (5/8) | 25% (1/4) |
| Fatigue2 | 33% (3/9) | 0% (0/4) |
| Weakness1 | 25% (2/8) | 0% (0/4) |
| Neurosensory | ||
| Vision Problems1 | 38% (3/8) | 0% (0/4) |
| Hearing Problems1 | 0% (0/9) | 0% (0/4) |
| Headache1 | 0% (0/3) | 50% (2/4) |
| Seizure2 | 63% (5/8) | 25% (1/4) |
| Tics2 | 11% (1/9) | 25% (1/4) |
| Strabismus2 | 44% (4/9) | 0% (0/4) |
| Psychiatric Problems | ||
| Bipolar Disorder2 | 0% (0/5) | 0% (0/4) |
| Anxiety Disorder2 | 29% (2/7) | 50% (2/4) |
| Obsessive-Compulsive Disorder2 | 44% (4/9) | 25% (1/4) |
| Attention Deficit Hyperactivity DO2 | 67% (6/9) | 25% (1/4) |
1Current or Previous with Moderate or Severe Severity.
2Current or Previous with Any Severity.