Table 1. Residues with high correlation scores and demonstrated (or suggested) importance for PPARγ function.

Residue	Location	Evidence supporting functional importance
I267	Ω-loop	I267A abolishes 15d-PGJ2 activation (ref. 43)
R357	Loop6-7	Forms salt bridge that locks a ligand exit pathway (ref. 54)
P467	H12	P467L attenuates ligand binding and coactivator recruitment (ref. 55)
E471	H12	Participates in the charge clamp (ref. 29)