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. 2016 Jan 29;7:20069. doi: 10.1038/srep20069

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(a) Effects of bovine or human PLG on reduction of TER in cells infected with GAS strains for 8 h. The TER value of the non-infected cells was set to 100%. All experiments were performed in sextuplet with three technical repeats. Data are shown as the mean ± S.D. of six wells from a representative experiment. *P < 0.01. (b) Caco-2 cells (left panel) or Detroit 562 cells (right panel) were infected with NIH35 or sen mutants at an MOI of 10 for 7 h in the presence of 1 μM human PLG. Cleavage of ZO-1, occludin, tricellulin, and E-cadherin was detected in whole cell lysates by Western blot analysis. β-actin served as a loading control.