Table 2.

Comparison of dynamics of laboratory tests over the course of MAS between patients classified as MAS or non-MAS by the expert panel*

Laboratory test	Patients classified as MAS (n=70)					Patients classified as non-MAS (n=33)					p Value†	p Value‡
	n	Value at last visit before MAS onset	Value at MAS onset	Absolute change	Percentage change	n	Value at last visit before MAS onset	Value at MAS onset	Absolute change	Percentage change
Hb, g/dL	70	11.2	9.9	−1.1	−10	33	11.5	10.8	−0.5	−5	0.070	0.030
WCC, ×109/L	70	15.0	7.4	−5.5	−50	33	10.8	12.0	1.6	11	<0.0001	<0.0001
N count, ×109/L	57	10.6	4.7	−5.5	−64	31	6.9	7.6	1.4	18	<0.0001	<0.0001
PLT, ×109/L	69	337	111	−209	−63	33	381	314	−62	−15	<0.0001	<0.0001
ESR, mm/h	62	59	26	−21	−39	26	33	61	8	59	<0.0001	<0.0001
AST, U/L	67	33	176	133	379	32	33	74	17	49	0.0002	0.0003
LDH, U/L	46	501	1735	1158	216	24	592	721	191	25	<0.0001	<0.0001
Triglycerides, mg/dL	42	120	257	116	111	13	93	126	32	33	0.006	0.020
Fibrinogen, mg/dL	44	456	201	−183	−47	20	510	454	−71	−22	0.010	0.010
Ferritin, ng/mL	60	875	10 516	7376	819	27	200	1183	548	282	<0.0001	0.03
D-dimer, ng/mL	23	1705	4620	2000	244	13	576	1237	300	100	0.09	0.19

*Values are the median (the IQRs can be provided on request to the authors). Absolute and percentage changes are the median values of the changes recorded in each individual patient.

†The p value refers to the comparison between absolute changes.

‡The p value refers to the comparison between percentage changes.

AST, aspartate aminotransferase; ESR, erythrocyte sedimentation rate; Hb, haemoglobin; LDH, lactate dehydrogenase; MAS, macrophage activation syndrome; N, neutrophils; PLT, platelets; WCC, white cell count.