Table 2. Associations between LTL and serum folate, vitamin B12, and HCY levels.
| Nutrients (median) |
Coefficient estimates ± SE for LTL* (p-value) | ||
|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |
| Folate | |||
| 1st quartile (4.8 ng/mL) | Reference | Reference | Reference |
| 2nd quartile (7.1 ng/mL) | 0.010 ± 0.040 (0.80) | -0.00013 ± 0.041 (1.00) | -0.010 ± 0.042 (0.87) |
| 3rd quartile (9.7 ng/mL) | 0.025 ± 0.041 (0.54) | 0.010 ± 0.042 (0.85) | 0.00019 ± 0.043 (1.00) |
| 4th quartile (15.8 ng/mL) | 0.051 ± 0.042 (0.22) | 0.042 ± 0.043 (0.33) | 0.040 ± 0.045 (0.37) |
| Vitamin B12 | |||
| 1st quartile (405 pg/mL) | Reference | Reference | Reference |
| 2nd quartile (530 pg/mL) | -0.012 ± 0.040 (0.77) | -0.010 ± 0.041 (0.87) | -0.010 ± 0.041 (0.83) |
| 3rd quartile (659 pg/mL) | 0.027 ± 0.040 (0.50) | 0.031 ± 0.040 (0.45) | 0.021 ± 0.041 (0.61) |
| 4th quartile (887 pg/mL) | -0.045 ± 0.040 (0.27) | -0.049 ± 0.041 (0.23) | -0.071 ± 0.042 (0.09) |
| HCY | |||
| 1st quartile (10.1 µmol/L) | Reference | Reference | Reference |
| 2nd quartile (12.1 µmol/L) | 0.023 ± 0.041 (0.58) | 0.034 ± 0.042 (0.41) | 0.036 ± 0.042 (0.39) |
| 3rd quartile (14.2 µmol/L) | 0.044 ± 0.042 (0.29) | 0.042 ± 0.042 (0.32) | 0.043 ± 0.043 (0.31) |
| 4th quartile (18.2 µmol/L) | -0.048 ± 0.045 (0.28) | -0.048 ± 0.045 (0.30) | -0.044 ± 0.046 (0.34) |
Model 1: Age and sex were adjusted for. Model 2: Age, sex, body mass index, smoking status, alcohol consumption, physical activity, the presence of diabetes mellitus, hypertension, or dyslipidemia, and serum high-sensitive C-reactive protein levels were adjusted for. Model 3: Covariates in model 2 and serum folate, vitamin B12, and HCY levels were adjusted for.
LTL: leukocyte telomere length, HCY: homocysteine, SE: standard error.
*Log-transformed value.