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. Author manuscript; available in PMC: 2016 Feb 1.
Published in final edited form as: Nat Chem Biol. 2015 Dec 7;12(2):87–93. doi: 10.1038/nchembio.1982

Figure 1. Inhibitors bind to a three-fold-symmetric cavity in prefusion RSV F.

Figure 1

(a) ITC data for the binding of JNJ-2408068 (left) and JNJ-49153390 (right) to prefusion RSV F (DS-Cav1). Red lines represent the best fit of titration data to a single-binding-site model. (b) Crystal structure of JNJ-2408068 bound to RSV F as viewed from the side. RSV F is shown as a molecular surface, except for the hydrophobic fusion peptides, which are shown as ribbons. An oval-shaped window into the central cavity has been created by removing a portion of the tan-colored protomer. Surfaces inside the cavity lack specular reflections. JNJ-2408068 is shown as a ball-and-stick representation with corresponding electron density shown as a blue mesh. (c) Top view of the structure shown in b, with the upper hemisphere of RSV F removed for clarity.