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. Author manuscript; available in PMC: 2016 Jan 29.
Published in final edited form as: Science. 2014 Feb 27;343(6176):1244–1248. doi: 10.1126/science.1249845

Fig. 3. RNA sequence recognition by RNase L.

Fig. 3

(A) Structure of RNA bound to the KEN homodimer. Arrows show the RNA trace. RNA cleavage is predicted at UN^N sites. (B) In trans activation of WT RNase L by the catalytically inactive RNase L mutant H672N. (C) RNase L cleavage of substrates I to VII. (D) RNase L cleavage of substrates DI and DII.