Table 3.
Atrial Fibrillation Susceptibility Alleles
| SNP | Chromosome Locus | Nearest Gene | Major/Minor Allele* | Copies of Risk Allele, %
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| VU
|
HCL
|
MGH
|
||||||||||
| 0 | 1 | 2 | 0 | 1 | 2 | 0 | 1 | 2 | ||||
| rs13376333 | 1q21 | KCNN3 | C/T | 42 | 46 | 12 | 42 | 46 | 12 | 46 | 49 | 5 |
| rs2200733 | 4q25 | PITX2 | C/T | 58 | 35 | 7 | 56 | 36 | 8 | 60 | 37 | 3 |
| rs10033464 | 4q25 | PITX2 | G/T | 79 | 19 | 2 | 77 | 22 | 1 | 72 | 28 | 0 |
| rs7193343 | 16q22 | ZFHX3 | C/T | 58 | 39 | 3 | 61 | 35 | 4 | 58 | 38 | 5 |
HCL indicates Heart Center Leipzig; MGH, Massachusetts General Hospital; SNP, single nucleotide polymorphism; and VU, Vanderbilt University.
*
The minor allele is the risk allele for all the SNPs.