. Author manuscript; available in PMC: 2016 Jan 29.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Feb 14;8(2):296–302. doi: 10.1161/CIRCEP.114.001909

Table 4.

Multivariable Analysis: Risk of Recurrence According to Risk Allele Status

SNP	Locus	Risk Allele	Combined		VU		HCL		MGH
SNP	Locus	Risk Allele	Adj. HR	P Value	Adj. HR	P Value	Adj. HR	P Value	Adj. HR	P Value
rs13376333	1q21	T	1.1 (0.9–1.4)	0.208	1.4 (0.9–2.1)	0.115	1.1 (0.9–1.5)	0.377	0.7 (0.4–1.5)	0.384
rs2200733	4q25	T	1.3 (1.1–1.6)	0.011	1.6 (1.0–2.4)	0.029	1.2 (0.9–1.6)	0.203	1.6 (0.8–3.2)	0.214
rs10033464	4q25	T	0.8 (0.6–1.1)	0.155	0.6 (0.4–1.1)	0.101	0.9 (0.7–1.3)	0.605	0.7 (0.3–1.7)	0.466
rs7193343	16q22	T	0.9 (0.7–1.1)	0.345	1.4 (0.9–2.1)	0.143	0.8 (0.6–1.0)	0.070	0.7 (0.3–1.4)	0.281

Recurrence includes AF, atrial flutter, or atrial tachycardia. Dominant genetic modeling is used for all SNPs. VU and HCL models are adjusted for age, sex, paroxysmal AF status, hypertension, BMI, LA diameter, and LVEF. The MGH model is adjusted for age and sex. The reference genotype is CC for rs2200733, rs7193343, and rs13376333. The reference genotype is GG for rs10033464. AF indicates atrial fibrillation; BMI, body mass index; HCL, Heart Center Leipzig; HR, hazard ratio; LA, left atrial; LVEF, left ventricular ejection fraction; MGH, Massachusetts General Hospital; SNP, single nucleotide polymorphism; and VU, Vanderbilt University.