. Author manuscript; available in PMC: 2016 Jan 29.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Feb 14;8(2):296–302. doi: 10.1161/CIRCEP.114.001909

Table 5.

Results of Multivariable Analysis for rs2200733 and Atrial Tachyarrhythmia Recurrence

SNP	VU		HCL		MGH
SNP	Adj. HR	P Value	Adj. HR	P Value	Adj. HR	P Value
rs2200733 (≥1 risk allele)	1.58 (1.05–2.38)	0.029	1.19 (0.91–1.56)	0.203	1.57 (0.77–3.17)	0.214
Age	0.99 (0.97–1.02)	0.597	1.01 (0.99–1.03)	0.181	1.01 (0.97–1.05)	0.667
Women	1.82 (1.15–2.88)	0.010	0.95 (0.69–1.31)	0.753	1.05 (0.42–2.63)	0.921
Paroxysmal AF	0.75 (0.48–1.19)	0.222	0.68 (0.51–0.91)	0.008	…	…
Hypertension	1.05 (0.67–1.67)	0.827	0.88 (0.62–1.24)	0.460	…	…
BMI (per 5 kg/m²)	0.78 (0.64–0.97)	0.023	1.01 (0.85–1.20)	0.905	…	…
LA diameter (per 5 mm)	1.19 (1.02–1.39)	0.025	1.12 (0.99–1.25)	0.067	…	…
LVEF (per 10%)	0.81 (0.67–0.99)	0.034	0.97 (0.83–1.12)	0.664	…	…

Recurrence includes AF, atrial flutter, or atrial tachycardia. Regression analysis was performed using a Cox Proportional Hazards model. Dominant genetic modeling is used for all SNPs. VU and HCL models are adjusted for age, sex paroxysmal AF status, hypertension, BMI, LA diameter, and LVEF. Because of sample size limitations, the MGH model is adjusted for age and sex. The reference genotype is CC for rs2200733. AF indicates atrial fibrillation; BMI, body mass index; HCL, Heart Center Leipzig; HR, hazard ratio; LA, left atrial; LVEF, left ventricular ejection fraction; MGH, Massachusetts General Hospital; SNP, single nucleotide polymorphism; and VU, Vanderbilt University.