Fig. 7.

Effects of RTA 408 on Grx1, Trx1, and NQO1 enzyme activities. RPE cells were pretreated with 100 nM RTA 408 for 24 h followed by 200 μM H₂O₂ for another 6 h. Quantitative analysis of Grx1 (A), Trx1 (B), and (C) NQO1 activity of all treatment groups (control, H₂O₂-treated, RTA 408 and H₂O₂-treated, and 100 nM RTA 408 only RPE cells) are depicted as mean±SD, **P<0.01, and ***P<0.001, comparing H₂O₂ only group (n=3).