Table 1.
HBPs differentially regulated in periodontal disease
| Protein name | Protien abbreviation |
|---|---|
| Up regulated HBPs | |
| ADAM metallopeptidase with thrombospondin type 1 motif, 1 | ADAMTS1 |
| Arginase, liver | ARG1 |
| Chemokine (C–C motif) ligand 19 | CCL19 |
| Complement factor H | CFH |
| Chemokine (C–X–C motif) ligand 1 | CXCL1 |
| Chemokine (C–X–C motif) ligand 12 | CXCL12 |
| Chemokine (C–X–C motif) ligand 13 (B cell chemoattractant) | CXCL13 |
| Chemokine (C–X–C motif) ligand 2 | CXCL2 |
| Chemokine (C–X–C motif) ligand 6 (granulocyte chemotactic protein 2) | CXCL6 |
| Fibronectin 1 | FN1 |
| Heparin-binding EGF-like growth factor | HBEGF |
| Insulin-like growth factor 2 mRNA binding protein 3 | IGFBP6 |
| Interleukin 10 | IL10 |
| Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | IL12B |
| Interleukin 6 (interferon, beta 2) | IL6 |
| Interleukin 8 | IL8 |
| Inhibin, beta A (activin A, activin AB alpha polypeptide) | INHBA |
| Lactotransferrin | LTF |
| Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) | MMP2 |
| Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) | MMP9 |
| Plasminogen activator, urokinase | PLAU |
| Serpine peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | SERPINE1 |
| Tenascin C (hexabrachion) | TNC |
| Tumour necrosis factor | TNF |
| Vascular endothelial growth factor | VEGFA |
| Down regulated HBPs | |
| Amyloid P component, serum | APCS |
| Chemokine (C–C motif) ligand 2 | CCL2 |
| Chemokine (C–C motif) ligand 3 | CCL3 |
| Chemokine (C–C motif) ligand 4 | CCL4 |
| Chemokine (C–C motif) ligand 5 | CCL5 |
| CD36 molecule | CD36 |
| Complement factor B | CFB |
| Connective tissue growth factor | CTGF |
| Chemokine (C–X–C motif) ligand 10 | CXCL10 |
| Fibroblast growth factor 2 (basic) | FGF2 |
| Fibroblast growth factor receptor 3 | FGFR3 |
| Fibronectin | FN1 |
| Glycoprotein (transmembrane) | GPNMB |
| Interferon, gamma | IFNG |
| Insulin-like growth factor binding protein 2, 36 kDa | IGFBP2 |
| Interleukin 2 | IL2 |
| Interleukin 6 (interferon, beta 2) | IL6 |
| Interleukin 8 | IL8 |
| Matrix metallopeptidase 14 (membrane-inserted) | MMP14 |
| Urokinase | PLAU |
| Thyroglobulin | TG |
| Thrombospondin 1 | THBS1 |
| Tumour necrosis factor | TNF |
Analyses using published data sets show 25 up-regulated and 23 down-regulated HBPs in periodontitis