Table 3: In Vivo miRNA Manipulation in the Context of AF.
| MiRNA | Species/model | MiRNA manipulation | Route of administration | References |
|---|---|---|---|---|
| Mir-1 | Rabbit ± RA tachypacing | Overexpression: lentivirus construct containing mir-1 precursor sequence | Direct i.m. Injection into RA | 31 |
| Knockdown: lentivirus construct containing anti-mir-1 oligonucleotide sequence | Direct i.m. Injection into RA | |||
| Mir-21 | Rat ± myocardial infarction | Knockdown: mir-21 antagomiR | Direct i.m. Injection into LA | 49 |
| Mir-21 | Mouse ± myocardial infarction | Knockdown: mir-21 antagomiR | Intravenous | 48 |
| Mir-26 | Mouse (wild type) | Overexpression: adeno-associated virus containing mir-26a mimic | Intravenous | 35 |
| Knockdown: adeno-associated virus containing anti-mir-26a sequence | Intravenous | |||
| Target protection: adeno-associated virus containing KCNJ2 mask | Intravenous | |||
| Mir-29b | Mouse (wild type) | Knockdown: adeno-associated virus containing anti-mir-29b sponge | Intravenous | 54 |
| Mir-328 | Dog ± RA tachypacing | Overexpression: adeno-associated virus containing mir-328 precursor sequence | Direct i.m. Injection into RA | 42 |
| Dog ± RA tachypacing | Knockdown: coinjection of mir-328 antagomiR | Direct i.m. Injection into RA | ||
| Mouse (wild type) | Knockdown: mir-328 antagomiR | Intravenous |
i.m. = intramuscular; LA = left atrium; RA = right atrium.