Table 1. Antiarrhythmic agents for pharmacological cardioversion*.
Agent | Primary dose regimen | Subsequent dose regimen | Notes |
---|---|---|---|
Amiodarone | 5 mg/kg BW IV over 1 h | approx. 50 mg/h | Potential acute adverse events: phlebitis. hypotension |
Flecainide | 2mg/kg BW IV over 10 min or 200–300 mg orally | Not in patients with marked structural heart disease. risk of QRS interval widening. QT prolongation. and atrial flutter with fast conduction | |
Propafenone | 2 mg/kg BW IV over 10 min or 450–600 mg orally | Not in patients with marked structural heart disease. risk of QRS interval widening and atrial flutter with fast conduction | |
Vernakalant | 3 mg/kg BW IV over 10 min | Limited approval |
*modified according to (4)