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. 2015 Oct 26;291(5):2087–2106. doi: 10.1074/jbc.M115.696419

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Inhibition of B-Raf(V600E)-mediated thrombin generation attenuated melanoma TEM. A, melanoma TEM was significantly increased by plasma treatment. The migration of 1 × 10⁶ WM35, A375M, UACC903, or Lu1205 melanoma cells across the HUVEC monolayer was assessed in a Boyden chamber in the presence or absence of PFP. **, p < 0.01 compared with −PFP; ††, p < 0.01 compared with no TC control. Values are mean ± S.E. B–D, silencing B-Raf(V600E) (B) or TF (C) or inhibition of thrombin with hirudin (D) dramatically reduced PFP-induced Lu1205 cell TEM. **, p < 0.01 compared with control cases. Values are mean ± S.E. E, p120-catenin S879A mutation attenuated PFP-induced Lu1205 cell TEM. **, p < 0.01 compared with control cases. Values are mean ± S.E. Immunoblots show the expression of S879A-p120 (150 kDa) in HUVECs. β-Tubulin served as a loading control.