TABLE 1.
Most up regulated and down regulated genes by HG and O-GlcNAcase inhibition (GNS) in Min6 cells presented as -fold change to LG
| Gene | Up-regulated genes |
Down-regulated genes |
Average -fold change | ||||
|---|---|---|---|---|---|---|---|
| HG/LG | GNS/LG | Average -fold change | Gene | LG/HG | LG/GNS | ||
| Bfsp1 | 25.9 | 26.0 | 25.9 | Myo1h | 236.1 | 94.1 | 165.1 |
| Slfn3 | 14.1 | 15.0 | 14.5 | Tcte3 | 14.2 | 14.2 | 14.2 |
| Gpr21 | 17.6 | 7.5 | 12.5 | Cyp4f40 | 23.7 | 3.1 | 13.4 |
| Ngef | 14.6 | 8.6 | 11.6 | Ip6k3 | 11.1 | 11.1 | 11.1 |
| Abcc9 | 14.1 | 7.5 | 10.8 | Krt25 | 9.6 | 12.2 | 10.9 |
| Adamts5 | 10.1 | 11.3 | 10.7 | Csf2rb2 | 10.1 | 10.1 | 10.1 |
| Grin3a | 4.0 | 16.9 | 10.5 | Creg2 | 2.7 | 17.2 | 9.9 |
| Trp73 | 13.1 | 7.5 | 10.3 | Saa3 | 6.1 | 11.9 | 9.0 |
| Srpk3 | 10.1 | 10.3 | 10.2 | Cntnap3 | 13.1 | 3.5 | 8.3 |
| Micall2 | 10.9 | 7.4 | 9.2 | Pla2g4a | 8.1 | 8.1 | 8.1 |
| Wnt16 | 12.1 | 5.6 | 8.9 | Col10a1 | 8.1 | 8.1 | 8.1 |
| Zfp459 | 8.6 | 8.4 | 8.5 | Fscn3 | 8.0 | 8.0 | 8.0 |
| Ccbe1 | 8.5 | 8.4 | 8.5 | Zmynd10 | 7.7 | 8.4 | 8.0 |
| Foxg1 | 5.0 | 11.1 | 8.0 | Odf312 | 13.2 | 2.0 | 7.6 |
| Gm 10335 | 2.8 | 12.8 | 7.8 | Lif | 5.0 | 10.1 | 7.6 |
| Gm 16485 | 9.9 | 5.6 | 7.8 | Slamf9 | 9.7 | 5.2 | 7.5 |
| Ptgds | 6.0 | 9.4 | 7.7 | Trh | 3.7 | 10.8 | 7.3 |
| Cdh15 | 10.1 | 5.3 | 7.7 | Gbgt1 | 4.5 | 9.1 | 6.8 |
| C1rl | 5.9 | 9.4 | 7.7 | Ifit3 | 8.8 | 4.7 | 6.8 |
| Smtnl1 | 8.0 | 7.4 | 7.7 | Gm14085 | 10.8 | 2.7 | 6.8 |
| Galnt7 | 9.4 | 5.8 | 7.6 | Nphs1 | 8.8 | 4.7 | 6.7 |
| Zfp114 | 8.6 | 6.5 | 7.5 | Tekt5 | 4.5 | 9.0 | 6.7 |
| Gp9 | 4.0 | 10.7 | 7.3 | Colec11 | 10.9 | 2.3 | 6.6 |
| Tal2 | 6.0 | 7.9 | 7.0 | Mmrn2 | 8.7 | 3.8 | 6.3 |
| Higd1a | 10.0 | 3.8 | 6.9 | Gdf10 | 8.1 | 4.3 | 6.2 |