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. 2015 Dec 7;291(5):2246–2259. doi: 10.1074/jbc.M115.686964

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Cycloheximide can improve GnRH sensing. Panel A, cells were treated as in Fig. 1, except that they were preincubated for 30 min in control medium (filled symbols) or with 30 μm CHX (open symbols) before GnRH stimulation. Single cell data were used to calculate I(ppERK;GnRH) as shown in panel B. 15-min data are omitted from panel A for clarity. A, two-way ANOVAs of the ppERK2 data revealed significant differences between control and CHX-treated cells at 30, 60, and 360 min. B, similar ANOVAs of the MI measures revealed a significant CHX effect, and post hoc Bonferroni tests revealed significant differences between control and CHX-treated cells 30, 60, and 360 min (*, p < 0.05; **, p < 0.01).