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. 2015 Dec 14;291(5):2371–2378. doi: 10.1074/jbc.M115.677351

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FIGURE 6. — Foxo1 activity negatively correlates with C/EBPα occupancy at the albumin promoter. A, ChIP sequencing profile for C/EBPβ at the albumin promoter. C/EBPβ binding sites selected for analyzing C/EBPα enrichment are indicated. B, enrichment of C/EBPα at the indicated sites of the albumin promoter in control (GFP, n = 4), AktDKO (n = 4), and FoxoTKO (n = 4) livers. Insulin served as a negative control site not bound by C/EBPα. **, p < 0.01 by two-way ANOVA. C, Western blotting analyses for C/EBPα and actin in liver homogenates of GFP, AktDKO, and FoxoTKO livers. D, model showing how insulin regulates albumin expression. All values are expressed as mean ± S.E.