TABLE 4.
KEGG analysis
This is a comparison of genes identified in the public ChIP-seq data set (mLiver-GW from GSE57305) with the PTCs-GW data set (PTCs-GW from GSE70296) according to selected categories in DAVID annotation. Genes identified under both “PTCs-GW” and “mLiver-GW” are bolded. GW, GW4064.
| Category | mLiver-GWa | PTCs-GW |
|---|---|---|
| Drug metabolism | CYP2D9, CYP3A25, CYP2A12, FMO5, GSTM3, UGT1A7C, ADH4, GSTK1, FMO3, GSTZ1, UGT1A2, GSTA2, GSTA4, GPX2, CYP3A13, CYP3A11, GSTT1, GSTT2, CYP2E1, UGT1A1, UGT1A10, AOX1, CYP2D26, CYP2C38, CYP2C39, MGST1, GSTA3 | Adh7, Cyp2d26, Gsta1, Gsta2, Gsta4, Gstm3, Gstm1, Ggt1, Gstt2, Gstz1, Gpx1, Gpx2 |
| Complement and coagulation cascades | KNG1, MBL1, KNG2, HC, C3, C4B, CFB, SERPINA1E, PLG, PROC, SERPINF2, CFH, C2, CFD, FGG, FGA, FGB, F2, SERPINE1, SERPINC1, CPB2 | C3, C4b, Fga, Serpina1e, Serpina1d, Serpina1c, Serpina1a, Serpinf2 |
| Metabolism of xenobiotics by cytochrome P450 | GSTA2, GSTA3, GSTA4, CYP3A25, CYP3A13, CYP3A11, GSTT1, GSTT2, CYP2E1, UGT1A1, DHDH, UGT1A10, GSTM3, UGT1A7C, GSTK1, ADH4, GSTZ1, UGT1A2, CYP2C38, CYP2C39, MGST1 | Adh7, Gsta1, Gsta2, Gsta4, Gstm3, Gstm1, Gstt2, Gstz1 |
| Pyruvate metabolic process | RBP4, GPD1, PCX, G6PC, SDS, PDK4, CAR5A, DLAT, AGXT, PCK1 | Acat2, Acot12, Akr1b7, Me3, Pcx |
| Fatty acid metabolic process | PTGES3, ACOX2, PRKAG3, HACL1, PPARA, PPARD, SC5D, PRKAG2, STAT5B, ACOT5, ACOT4, ACOT3, PECR, APOA2, ACSL1, ELOVL5, FASN, ACOT12, ELOVL6, ACAA1B, ACSL5, SCD1, CPT1B, ACADM, ALDH5A1, EPHX2, ADIPOR2, LYPLA2, PHYH, ADIPOQ, CPT1A, BRCA1, QK, PTGDS, MAPK14, LIPC, AACS, SLC27A2, CROT, SLC27A4, DEGS1 | Acat2, Adh7, Cyp4a12b, Cyp4a12a, Acot3, Acot4, Acot5, Baat; Acaa1a; Acnat1; Acot1; Acot12; Acox2; Acsm1; Akr1b7; Aoah; Apob48r; Apoe, Cubn; Cyp24a1; Enpp6; Hnf4a; Mogat2; Pcx; Pla1a; Pla2g12b; Pnpla3; Soat2; Sult1a1, Prkag2; Slc27a3; Slc37a4 |
| Oxidation reduction | CYP2D9, ACOX2, CYP2J5, STEAP3, LDHA, SC5D, ALDH1L1, PRDX5, PDHB, GPX2, RDH9, PECR, CYP7A1, CPOX, SRD5A1, DHTKD1, DUS1L, SARDH, GFOD1, DHCR24, HPD, SQRDL, ACADM, CYP3A13, ALDH5A1, CYP3A11, CYCS, DECR2, QDPR, CYP26A1, RDH1, CYP2E1, GRHPR, CDO1, POR, DHDH, CYP27A1, H6PD, SLC37A2, CYP2D26, TXNRD2, DEGS1, CYP2U1, XDH, CYP3A25, NDUFB6, HSD17B2, HSD17B1, HSD17B13, AASS, MOSC2, EGLN2, Kmo, PAH, ALDH3A2, PIPOX, CYP2A12, FMO5, ADH4, FMO3, HAAO, FASN, BDH1, BCKDHA, SCD1, CYP2G1, GPD1, CHDH, CYP21A1, HGD, PHYH, AKR1B7, CYP17A1, SLC25A13, LEPRE1, UOX, NDUFV1, CYP4F15, AOX1, PRODH2, CP, CYP2C38, CYP4A14, ACAD10, ALKBH2, CYP2C39 | Haao, Egln3, Adh7, Fa2h, Gclm, Gpx1, Gldc, Hgd, Hsd3b2, Hsd3b3, Me3, Miox, Hsd3b4, Acad10, Acox2; Adhfe1; Akr1b7; Aldh1a3; Cat; Cmah, Cyp2d26, Cyp2j11-ps, Cyp24a1, Cyp24a1; Cyp2c29; Cyp2c44; Cyp2j13; Cyp2j9; Cyp4a12b, Cyp4a12a; Dcxr; Dhcr24; Dus1l; Dus2l; Gldc; Gpd1; Gsr; Hsd11b1; Hsd17b2; Hsd3b3; Kmo; Maoa; Maob; Nqo1; Prodh2; Qdpr; Qsox1; Sardh; Sdr42e1; Slc37a4, Sord; Steap3; Xdh |
| Glycerophospholipid metabolism | CHPT1, GPD1, PEMT, PLA2G6, AGPAT2, AGPAT1, CRLS1, NAT6, PPAP2C, CHKB, LYPLA2, LCAT, PHOSPHO1 | Agpat2; Etnk1; Pemt; Pi4k2a; Pla2g5 |