FIGURE 1.

Conserved regions specific to the Ded1/DDX3 subfamily of DEAD-box proteins. A, a linear diagram of the features of the Ded1/DDX3 family, including the core helicase DEAD and HELICc RecA-like domains, the Crm1-dependent nuclear export sequence (NES), and the eIF4E-binding site. Conserved regions specific to the Ded1/DDX3 subfamily are indicated in gray; GINF, RDYR, and WW refer to amino acid motifs. The NTE and CTE are indicated. B, sequence alignments showing the N- and C-terminal extensions found in the Ded1/DDX3 family and indicating construct boundaries used in this study and two previous crystal structures. Numbers correspond to human DDX3X.