TABLE 1.

Properties of AC inhibitors used in the present study

Shown are chemical structures, inhibitory potencies (IC₅₀) on human AC, and stability profile of compounds ARN398 and ARN14988.

^a IC₅₀ values are expressed as the means of three determinations.

^b Chemical stability was determined by ¹H NMR analysis of the compound in a DMSO-d₆ solution. Stable compounds showed < 10% degradation after 120 min.

^c Mouse plasma, 37°C.