Table 4. Points of departure for lesions in naphthalene-exposed rats from NTP (NTP 2000) and Dodd et al. (2012)*.

Nasal tissue	Sex	Lesion	Point of departure (POD) based on Best-fit model estimate			Point of departure (POD) based on average model (AM) estimate				Data Source
			Best-Fit dose–response model	BMD (BMD10)	POD (BMDL10)	Number of Models	AM_BMD	AM_POD	BMDL Range
Ventral respiratory epithelium	Male	Hyperplasia	Weibull	3.252	0.827	6	2.00	0.781	0.261	Dodd et al. 2012
			Logistic	2.760	2.190	6	3.55	1.412	1.550	NTP 2000
		Squamous metaplasia	Gamma	4.529	3.737	7	5.12	3.819	1.515	Dodd et al. 2012
			LogLogistic	1.360	1.030	4	1.89	1.529	1.371	NTP 2000
	Female	Hyperplasia	LogProbit	5.327	4.253	7	4.99	3.843	1.685	Dodd et al. 2012
			LogProbit	3.361	2.162	6	3.51	2.002	2.529	NTP 2000
		Squamous metaplasia	LogProbit	5.253	4.152	7	4.95	3.742	1.541	Dodd et al. 2012
			LogLogistic	1.519	1.148	4	2.06	1.661	1.420	NTP 2000
Olfactory epithelium	Male	Degeneration	LogLogistic	3.364	1.298	7	4.41	1.245	0.207	Dodd et al. 2012
		Hyperplasia	LogLogistic	8.005	1.341	7	6.83	1.601	1.430	Dodd et al. 2012
			LogLogistic	0.077	0.036	1	NA	NA	NA	NTP 2000
	Female	Degeneration	LogLogistic	3.364	1.298	7	4.41	1.245	0.207	Dodd et al. 2012
		Hyperplasia	LogLogistic	3.364	1.298	7	4.41	1.245	0.207	Dodd et al. 2012

BMD = benchmark dose, BMDL₁₀ = 95% lower confidence limit on the benchmark dose (10% response), POD = point of departure, NA = not applicable.

Average Model (AM): The average model estimates are the arithmetic average BMD or BMDL from all models that adequately fit the data.

BMDL Range = Max BMDL – Min BMDL.

*Data are in units of the amount of naphthalene metabolized in the rat (nmol/min-g tissue) (Using md_v.4 estimates).