Table II. Pharmacokinetic characteristics of the three asparaginase formulations [30,31].*.

	Erwinia asparaginase	Native E. coli asparaginase	PEG-asparaginase
Half-life (mean ± SD)	0.65 ± 0.13 days	1.28 ± 0.35 days	5.73 ± 3.24 days
Asparagine depletion	7–15 days	14–23 days	26–34 days
Peak asparaginase activity	Within 24 h	24–48 h	72–96 h

SD, standard deviation; PEG, pegylated.

*Adapted with permission from Asselin, 1999 [30].