Table 3.

Grading of recommendations regarding the strength and underlying evidence; adapted from the GRADE system used by EASL.

Evidence quality	Definition
High	Further research is very unlikely to change the confidence in the estimate of effect	A
Moderate	Further research is likely to have an important impact on the confidence in the estimate of effect and may change the estimate	B
Low	Further research is very likely to have an important impact on the confidence in the estimate of effect and is likely to change the estimate	C
	Any change of estimate is uncertain
Recommendation
Strong	Factors influencing the strength of the recommendation included the quality of the evidence, presumed patient-important outcomes and cost	1
Weak	Variability in preferences and values or more uncertainty. Recommendation is made with less certainty, higher cost or resource consumption	2