Table 1.

miRNA as a biomarker of radiation injury and countermeasure efficacy.

miRNA	Biomarker for	Effects	Experimental Details	References
miR-34b-3p	TBI	Fold change 2.0 ⇑	B6D2F1/J mice, 60Co, 9.5 Gy, 0.4 Gy/min	[55]
miR-3082-5p		Fold change 2.0 ⇑
miR-142-5p		Fold change 1.5 ⇓
miR-31		Fold change 1.5 ⇓
miR-185		Fold change 1.6 ⇓
miR-130b		Fold change 1.7 ⇓
miR-216b		Fold change 1.7 ⇓
miR-130a		Fold change 1.9 ⇓
miR-1912		Fold change 2.1 ⇓
miR-150	TBI and PBI	Down regulated	CBA/J and C57BL/6 mice, 137Cs, 1–12 Gy, 1.1 Gy/min	[56]
miR-200b		Upregulated
miR-762		Upregulated
miR-30b	TBI	Upregulated	CD2F1 mice, 60Co, 7 or 10 Gy, 0.6 Gy/min	[57]
miR-30c		Upregulated
miR-30a-3p	TBI	Upregulated	C57BL/6 J mice, 137Cs, 8 Gy, 1.1 Gy/min	[58]
miR-30c-5p		Upregulated
miR-187-3p		Downregulated
miR-194-5p		Downregulated
miR-27a-3p		Downregulated
miR-667	TBI	Differentially	C57BL6 mice, 137Cs, 0.5, 2 and 10 Gy, 0.52 Gy/min	[59]
miR-877		Changed at 6 and 24 h postirradiation with 0, 2, and 10 Gy
miR-24–2
miR-434-5p
miR-501-3p
miR-592
miR-148a
miR-30a
miR-30e
miR-690	CI: TBI and burn	Fold change 1.8 ⇑	B6D2F1/J mice, 60Co, 9.5 Gy, 0.4 Gy/min	[55]
miR-223		Fold change 1.2 ⇑
miR-30b	δ-tocotrienol (75 mg/kg) in TBI model	Downregulated radiation-induced miRNA	CD2F1 mice, 60Co, 7 or 10 Gy, 0.6 Gy/min	[57]
miR-30c
miR-30a-3p	Amifostine, TBI	Downregulated	C57BL/6 J mice, 137Cs, 8 Gy, 1.1 Gy/min	[58]
miR-30c-5p		Downregulated
miR-187-3p		Upregulated
miR-194-5p		Upregulated
miR-27a-3p		Upregulated
miR-30a-3p	Bone marrow stromal cells, TBI	Downregulated	C57BL/6 J mice, 137Cs, 10.4 Gy, 1.1 Gy/min	[58]
miR-30c-5p		Downregulated
miR-187-3p		Upregulated
miR-27a-3p		Upregulated

Only in vivo models have been reviewed. CI, combined injury; PBI, partial-body irradiation; TBI, total-body irradiation.