Table 1. Characteristics of the studies included. The main characteristics of the studies regarding the place where they were conducted, the inclusion criteria for participants and the follow-up to assess recurrences is shown*.

Region	First author	Blood schizonticide + Intervention/comparison	Dose adjustment for body weight greater than 60 kg	Endemic region	Population	Inclusion criteria parasitemia diagnosis day (# parasites/µl)	G6PDH test before administering PQ	Simultaneous treatment blood schizonticide and PQ	Supervision treatment	Genoyping for clasiffication recurrences (relapse or reinfection)
America	Pinto, et al 18 Brazil	CQ 10 mg/kg single dose + PQ 0.5 mg/kg/day 7 days	Not applicable	Yes	Community, children between 0 and 15 years old	No	No	Not specified	Not specified	No
	Abdon, et al 15 Brazil	CQ 25 mg/kg 3 days + PQ 0.25 mg/kg/day 14 days	Not specified	Yes	Community, age higher than 12 years	No	Not specified	Not specified	Yes	No
		CQ 10 mg/kg single dose + PQ 0.5 mg/kg/day 7 days						Not specified	Yes
	Solari-Soto, et al 20 Peru	CQ 25 mg/Kg + PQ 0.25 mg/kg/day 14 days	Not specified	Yes	Community, age higher than 12 years	No	Not specified	Yes	Yes	No
		CQ 25 mg/Kg + PQ 0.5 mg/kg/day 7 days							Yes
	Da Silva, et al 16 Brazil	AS 50 mg 0h and 12h + PQ 30 mg/d 7 days	No	Yes	Community, age higher than 14 years	No	Not specified	Not specified	Not specified	No
		AS 100 mg 0h and 12h + PQ 30 mg/d 7 days
		AS 100 mg 0h and 50 mg 12h + PQ 30 mg/d 7 days
		CQ 600mg single dose + PQ 30 mg/kg/d 7 days
	Carmona-Fonseca, et al 21 Colombia	CQ 25mg/Kg in 3 days + PQ 210 mg in 7 days	Not specified	Yes	Community, children under18 years old	Yes; 1000 or more parasites/µl	Yes	Yes	Yes	No
	Durand, et al 17 Perú	CQ 25 mg / kg 3días + PQ 0,5 mg/kg/day 7 days	Not specified	Yes	Community, age higher than 1 year	Yes; between 250 - 100000 parasites/µl	Yes	Yes	Yes	Yes
		CQ 25 mg/kg 3 días + PQ 0,25 mg/kg/day 14 days	Not specified	Yes					Yes
Southeast Asian	Sutanto, et al 23 Indonesia	Quinina (10 mg/kg 3 time by day, 7 days) + PQ 30 mg/day 14 days	Yes; maximum 45 mg/day, PQ in participant greater than 70 kg.	No	Soldiers	No	Yes	Yes	Not specified	Not applicable. All recurrences are relapse
		Dihidroartemisinina (120 mg) - piperaquina (960 mg)/day, 3 days + PQ after day 28; 30 mg/day, 14 days						No; PQ after finishing blood schizonticide	Not specified
	Rajgor, et al 19 India	CQ 25 mg/kg 3 days + PQ 15mg/day, 14 days	Not specified	Yes	Community, age higher than 18 years	No	Yes	No, PQ 24 hours after last CQ dosage	Yes	Yes
		CQ 25 mg/kg 3 days + PQ 30 mg/day, 7 days
		CQ 25 mg/kg 3 days + PQ 30 mg/day, 14 days
Eastern Mediterranean	Leslie, et al 22 2008 Pakistan	CQ 25 mg/kg 3 days + PQ 0.5 mg/kg/day, 14 days	Not specified	Yes	Community, age higher than 3 years	No	Yes	Yes	Yes	No

G6PDH, Glucose 6-phosphate deshidrogenase, PQ, Primaquine, CQ, Chloroquine, AS, Artesunate

* All diagnosis test were made by microscopy