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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2015 May 13;1849(7):836–844. doi: 10.1016/j.bbagrm.2015.05.002

Figure 3. Putative eIF5A regulon.

Figure 3

Hypusine-containing eIF5A is proposed to affect protein expression by enhancing the translation of Group 1 mRNAs (resulting in up-regulation), and the turnover of Group 2 mRNAs (resulting in down-regulation). The targets may be direct or secondary to eIF5A's biochemical action, are collectively considered the eIF5A regulon, and influence tumorigenesis and related cellular processes. (Reproduced from Mémin et al. [23] as permitted by AACR.)