Table 3. HRs of CHD Outcomes by Categories of Thyrotropin Levels at Baseline, Overall, and by Sex and Age at Baselinea.
| Thyrotropin, mIU/Lb | CHD Mortality | CHD Events | CHD Hard Eventsc | |||
|---|---|---|---|---|---|---|
| No. of Events/Participants | HR (95% CI) | No. of Events/Participants | HR (95% CI) | No. of Events/Participants | HR (95% CI) | |
| Overall | ||||||
| 0.45-1.49 | 695/23 785 | 1 [Reference] | 1857/20 791 | 1 [Reference] | 970/14 828 | 1 [Reference] |
| 1.50-2.49 | 678/19 996 | 0.99 (0.86-1.14) | 1757/18 748 | 1.00 (0.89-1.11) | 945/13 096 | 1.00 (0.88-1.13) |
| 2.50-3.49 | 303/7636 | 0.99 (0.84-1.17) | 747/6702 | 1.01 (0.92-1.11) | 414/4572 | 1.06 (0.94-1.21) |
| 3.50-4.49 | 132/3232 | 0.94 (0.74-1.20) | 305/2634 | 0.97 (0.83-1.13) | 159/1760 | 0.95 (0.78-1.16) |
| Women | ||||||
| 0.45-1.49 | 309/13 689 | 1 [Reference] | 776/12 359 | 1 [Reference] | 456/9422 | 1 [Reference] |
| 1.50-2.49 | 303/11 799 | 0.84 (0.65-1.09) | 766/11 285 | 0.94 (0.82-1.09) | 460/8346 | 0.91 (0.73-1.14) |
| 2.50-3.49 | 143/4711 | 0.93 (0.74-1.17) | 349/4232 | 0.98 (0.83-1.16) | 221/3023 | 1.13 (0.95-1.34) |
| 3.50-4.49 | 75/2144 | 0.88 (0.62-1.23) | 172/1811 | 0.98 (0.80-1.19) | 92/1240 | 0.91 (0.68-1.21) |
| Men | ||||||
| 0.45-1.49 | 386/10 096 | 1 [Reference] | 1081/8432 | 1 [Reference] | 514/5406 | 1 [Reference] |
| 1.50-2.49 | 375/8197 | 1.13 (0.90-1.40) | 991/7463 | 1.03 (0.91-1.17) | 485/4750 | 1.03 (0.90-1.18) |
| 2.50-3.49 | 160/2925 | 1.12 (0.92-1.35) | 398/2470 | 1.05 (0.90-1.22) | 193/1549 | 1.03 (0.82-1.30) |
| 3.50-4.49 | 57/1088 | 1.02 (0.76-1.36) | 133/823 | 1.00 (0.76-1.31) | 67/520 | 1.03 (0.78-1.36) |
| Age <65 y | ||||||
| 0.45-1.49 | 161/16 000 | 1 [Reference] | 748/13 769 | 1 [Reference] | 294/9200 | 1 [Reference] |
| 1.50-2.49 | 117/12 306 | 0.96 (0.69-1.33) | 560/11 611 | 0.93 (0.73-1.18) | 191/7358 | 0.96 (0.60-1.53) |
| 2.50-3.49 | 39/4182 | 0.97 (0.68-1.38) | 168/3594 | 0.85 (0.70-1.03) | 51/2072 | 0.86 (0.63-1.16) |
| 3.50-4.49 | 13/1676 | 0.83 (0.46-1.52) | 74/1303 | 1.02 (0.78-1.34) | 22/677 | 1.26 (0.76-2.09) |
| Age 65-79 y | ||||||
| 0.45-1.49 | 431/6862 | 1 [Reference] | 958/6152 | 1 [Reference] | 547/4777 | 1 [Reference] |
| 1.50-2.49 | 431/6680 | 1.03 (0.85-1.25) | 1000/6190 | 1.05 (0.93-1.18) | 592/4808 | 1.02 (0.83-1.26) |
| 2.50-3.49 | 210/3018 | 1.04 (0.85-1.26) | 495/2717 | 1.11 (0.99-1.25) | 290/2119 | 1.13 (0.97-1.31) |
| 3.50-4.49 | 83/1310 | 1.00 (0.77-1.29) | 189/1124 | 1.02 (0.81-1.29) | 97/882 | 0.91 (0.73-1.14) |
| Age ≥80 y | ||||||
| 0.45-1.49 | 103/923 | 1 [Reference] | 151/870 | 1 [Reference] | 129/851 | 1 [Reference] |
| 1.50-2.49 | 130/1010 | 1.08 (0.74-1.56) | 197/947 | 1.18 (0.95-1.47) | 162/930 | 1.04 (0.75-1.46) |
| 2.50-3.49 | 54/436 | 1.03 (0.69-1.53) | 84/391 | 1.18 (0.90-1.55) | 73/381 | 1.17 (0.85-1.61) |
| 3.50-4.49 | 36/246 | 1.27 (0.77-2.07) | 42/207 | 1.26 (0.88-1.79) | 40/201 | 1.23 (0.82-1.85) |
Abbreviations: CHD, coronary heart disease; HR, hazard ratio.
a
Adjusted for age, sex and smoking at baseline.
b
For the Whickham Survey,31,34 which used a first-generation thyrotropin assay, the following categories were used: 0.5 to 1.8, 1.9 to 3.2, 3.3 to 4.6, and 4.7 to 5.9 mIU/L.
c
Defined as CHD mortality or myocardial infarction.