Table 1.
MetPa analysis of pathways altered in ΔwhiB3 compared to Wt Mtba.
| KEGG Pathway Name | Metabolites | p-value | Impact | |
|---|---|---|---|---|
| Total | Hits | |||
| Arginine and proline metabolism | 41 | 12 | 0.000189 | 0.19 |
| Glycine, serine and threonine metabolism | 32 | 10 | 0.000378 | 0.60 |
| Lysine biosynthesis | 13 | 6 | 0.000588 | 0.38 |
| Pantothenate and CoA biosynthesis | 23 | 8 | 0.000681 | 0.41 |
| Butanoate metabolism | 18 | 7 | 0.000699 | 0.32 |
| Valine, leucine and isoleucine biosynthesis | 26 | 8 | 0.00171 | 0.24 |
| Cysteine and methionine metabolism | 34 | 9 | 0.00282 | 0.34 |
| Alanine, aspartate and glutamine metabolism | 18 | 6 | 0.0043 | 0.66 |
| Citrate cycle (TCA cycle) | 20 | 5 | 0.0327 | 0.11 |
a
Metabolomic Pathway Analysis (MetPA) combines pathway enrichment analysis with pathway topology analysis to identify the most relevant pathways under the specified conditions. MetPA uses the KEGG metabolic pathways as the backend knowledge base and integrates univariate analysis, over-representation analysis, Global Test, GlobalAncova and network topology analysis into pathway analysis. The total/maximum importance of each pathway = 1; pathway impact value = cumulative % from the matched metabolic nodes. Pathways with the most significant change (p ≤ 0.05) are listed. KEGG; Kyoto Encyclopedia of Genes and Genomes, TCA; tricarboxylic acid. See also Table S1.