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. 2016 Jan 29;11(1):e0147764. doi: 10.1371/journal.pone.0147764

Fig 7. Schematic diagram of FoxC2-mediated biological effects on the BMP7-SMAD signaling pathways.

Fig 7

BMP/Smad signaling pathway can upregulate FoxC2 expression in the NP cells. FoxC2 inhibits the production of noggin and enhances BMP7-mediated anabolism, what was a positive feedback for maintaining signal activation.