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. 2016 Jan 29;11(1):e0148137. doi: 10.1371/journal.pone.0148137

Fig 8. Hypothesis of S1P-induced migration of neoplastic T-cell progenitors:

Fig 8

(A) S1P-induced chemotaxis: cells expressing S1P1 migrate toward low S1P concentrations (10–100 nM) and migration is inhibited when S1P1 is blocked with W146. In contrast, cells do not migrate toward high S1P concentrations (500–10000 nM), unless when S1P1 is blocked. (B) S1P-induced fugetaxis: cells expressing S1P1 do not migrate away from low S1P concentrations and the nonspecific migration observed is even smaller when S1P1 is blocked. However, cells migrate away from high S1P concentrations and migration is impaired when S1P1 is blocked.