Fig 1. A conserved C7D2 transporter in microbiomes from CD patients and unaffected first-degree relatives (CDR).

(A) Boxplot representation of percent identities between C7D2, H11G11 or GusB transporters and homologs from CDR and CDU microbiomes. (B) Analysis restricted to Spanish subjects and homologs of C7D2 transporter. Homologs of H11G11 and C7D2 transporters were searched, using the tBlastn tool, in human gut microbiomes from sick and healthy first-degree relatives CD related (together referred to as CDR) and CD unrelated healthy subjects. Representation was performed per query (C7D2, H11G11 and GusB transporters) for each disease status. Results are presented as percent amino acid identity between each query and homologs recovered from microbiome sequences. Comparisons of variance between amino acid sequence convergence of CDR and CDU transporters or between Spanish CD, unaffected relatives and healthy subjects were performed using a Mann-Whitney U-Test.