Size of spontaneous lesions (shaded bars) as well as angioplasty-induced intimal hyperplasia (open bars) increases with increasing blood cholesterol achieved by feeding animals a cholesterol diet supplemented with either 0.5% or 2% cholesterol. TC, total cholesterol; I/M ratio, intimal area-to-medial area ratio. ¶P < 0.001, 0.5% diet vs. control diet; §P < 0.05, 2% diet vs. 0.5% diet; *P < 0.01, 0.5% diet vs control diet; †P < 0.01, 2% diet vs. 0.5% diet. n ≥ 6 animals. Statistical analysis was by ANOVA.