Change in expression of each gene from baseline. Mean (95% CI) for gene expression ratio (Week 12: baseline), on the log2 scale, after adjustment for baseline gene expression. Log2 of the gene expression ratio equals, if positive, the number of time expression doubled in 12 weeks, if negative, the number of times expression was halved. P-values are for the overall treatment effect (df=2) after adjustment for baseline expression levels (ANCOVA).