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. Author manuscript; available in PMC: 2016 Jan 29.
Published in final edited form as: J Endocrinol. 2009 Jan 14;201(1):129–139. doi: 10.1677/JOE-08-0476

Figure 8.

Figure 8

SB203580 effectively prevents T-induced activation of Notch signaling and muscle cell proliferation. (A) Representative western blots of muscle lysates from control (C), testosterone (T), and testosterone + inhibitor (T+I) treated mice show effective suppression of T-induced Delta 1, Notch 1, Notch 2, and PCNA levels by SB203580. The gels are representative of two animals at each time point from one of three separate experiments. GAPDH in the immunoblot is shown as a loading control. Densitometric analysis shows a significant increase in the expression of these proteins 2 week after T treatment and which can be significantly suppressed by inhibition of p38 MAPK (B–E). Values are mean±s.e.m. of six animals. Means with unlike superscripts are significantly (P<0.001) different.