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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Jun 26;8(1):123–138. doi: 10.1002/wnan.1350

Figure 2. Oligonucleotide origami uses single stranded DNA (ssDNA) springs to engineer precision joints.

Figure 2

Two arms composed of 3 bundles of double stranded DNA (18 helices total) were linked by a single rigid bundle (6 helices) as well as a ssDNA spring. The length of the spring was modified to produce different angles. Conformational analysis was performed using TEM imaging. Typical particles and histogram distribution are presented with A) 0, B) 11, C) 32, D) 53, and E) 74 bases in the ssDNA springs. The black lines show Gaussian fits to the data. The angles corresponding to the peak values of Gaussian fits were 56.5° (n = 154), 70.2° (n = 213), 97.9° (n = 169), 110.0° (n = 252), 128.2° (n = 204). Bars = 20 nm. Adapted with permission from the American Chemical Society28.