Table 6. Results for the Replication in Athletes and Controls from Kenya and Ethiopia; Results in bold type are for p ≤0.05.
| Meta-analysis | Kenya | Ethiopia | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chr | MAP | Gene* | Effect allele | OR | P | Q | I2 | OR | P | OR | P |
| rs10874242 | 1 | 81,426,166 | LPHN2 (153 kb) | T | 1.39 | 0.11 | 0.22 | 32.9 | 1.14 | 0.58 | 1.70 | 0.02 |
| rs12047209 | 1 | 243,791,105 | AKT3 | C | 0.74 | 0.67 | 0.02 | 82.5 | 0.37 | 0.01 | 1.52 | 0.33 |
| rs921665 | 2 | 3,170,550 | TSSC1 (18 kb) | A | 0.75 | 0.03 | 0.33 | 0.0 | 0.67 | 0.02 | 0.87 | 0.51 |
| rs2694093 | 2 | 3,254,403 | TSSC1 | G | 0.94 | 0.70 | 0.84 | 0.0 | 0.97 | 0.89 | 0.91 | 0.68 |
| rs6726044 | 2 | 68,911,860 | BMP10 (40 kb) | A | 1.07 | 0.85 | 0.02 | 81.7 | 1.57 | 0.04 | 0.73 | 0.19 |
| rs2118908 | 2 | 111,067,015 | ACOXL | G | 0.98 | 0.94 | 0.98 | 0.0 | 0.98 | 0.94 | 0.99 | 0.98 |
| rs7650685 | 3 | 11,660,982 | VGLL4 | G | 0.98 | 0.90 | 0.61 | 0.0 | 1.05 | 0.80 | 0.92 | 0.65 |
| rs6799372 | 3 | 74,481,495 | CNTN3 | A | 1.39 | 0.04 | 0.92 | 0.0 | 1.37 | 0.16 | 1.42 | 0.13 |
| rs10938202 | 4 | 42,650,320 | ATP8A1 | C | 0.57 | 0.07 | 0.21 | 35.4 | 0.74 | 0.31 | 0.40 | 0.02 |
| rs10007111 | 4 | 87,828,549 | MEPE | A | 1.03 | 0.95 | 0.02 | 82.2 | 1.51 | 0.05 | 0.68 | 0.14 |
| rs4699824 | 4 | 100,801,328 | EMCN (283 kb), PPP3CA (222 kb) | A | 1.00 | 0.98 | 0.64 | 0.0 | 1.07 | 0.74 | 0.94 | 0.73 |
| rs558129 | 4 | 171,829,960 | GALNTL6 | T | 0.80 | 0.15 | 0.44 | 0.0 | 0.72 | 0.11 | 0.91 | 0.69 |
| rs2910756 | 5 | 37,859,972 | GDNF-AS1 | G | 0.74 | 0.04 | 0.35 | 0.0 | 0.82 | 0.27 | 0.62 | 0.04 |
| rs10499127 | 6 | 124,594,509 | NKAIN2 | G | 0.92 | 0.67 | 0.37 | 0.0 | 0.75 | 0.34 | 1.08 | 0.78 |
| rs9355947 | 6 | 161,887,402 | PARK2 | G | 0.93 | 0.60 | 0.73 | 0.0 | 0.89 | 0.54 | 0.98 | 0.90 |
| rs11975386 | 7 | 94,075,721 | BET1 (70 kb) | A | 1.05 | 0.83 | 0.83 | 0.0 | 1.09 | 0.76 | 0.99 | 0.98 |
| rs17055965 | 8 | 26,769,562 | ADRA1A | G | 1.27 | 0.37 | 0.70 | 0.0 | 1.44 | 0.39 | 1.17 | 0.64 |
| rs16906888 | 8 | 137,231,375 | FAM135B (898 kb) | G | 1.12 | 0.40 | 0.46 | 0.0 | 1.23 | 0.27 | 1.01 | 0.98 |
| rs7861665 | 9 | 4,302,988 | LOC101929330, GLIS3 (3 kb) | T | 0.81 | 0.13 | 0.70 | 0.0 | 0.78 | 0.16 | 0.87 | 0.51 |
| rs3780169 | 9 | 36,979,398 | PAX5 | T | 0.80 | 0.12 | 0.32 | 0.0 | 0.90 | 0.59 | 0.68 | 0.08 |
| rs17054974 | 9 | 89,549,371 | SEMA4D (51 kb), GADD45G (55 kb) | C | 1.08 | 0.87 | 0.13 | 57.4 | 1.75 | 0.21 | 0.71 | 0.36 |
| rs17690338 | 10 | 75,357,798 | ZNF503-AS1 | A | 1.02 | 0.92 | 0.19 | 42.4 | 1.24 | 0.31 | 0.84 | 0.40 |
| rs12573965 | 11 | 2,660,402 | KCNQ1 | C | 0.82 | 0.90 | 0.01 | 86.3 | 0.19 | 0.005 | 4.02 | 0.10 |
| rs7947391 | 11 | 66,419,411 | NPAS4 | G | 0.75 | 0.03 | 0.71 | 0.0 | 0.71 | 0.06 | 0.79 | 0.21 |
| rs61940911 | 12 | 110,029,339 | ANKRD13A | T | 1.23 | 0.57 | 0.69 | 0.0 | 0.98 | 0.98 | 1.34 | 0.48 |
| rs73195844 | 12 | 110,906,768 | CCDC63, MYL2 (4 kb) | T | 1.43 | 0.29 | 0.93 | 0.0 | 1.51 | 0.59 | 1.41 | 0.35 |
| rs9543114 | 13 | 72,767,956 | DIS3 | C | 1.37 | 0.56 | 0.92 | 0.0 | 1.51 | 0.71 | 1.33 | 0.65 |
| rs9301108 | 13 | 106,143,743 | DAOA (653 kb), EFNB2 (346 kb) | C | 0.82 | 0.69 | 0.00 | 87.9 | 0.50 | 0.0008 | 1.38 | 0.26 |
| rs214003 | 14 | 78,336,687 | NRXN3 | G | 0.86 | 0.38 | 0.21 | 36.3 | 0.74 | 0.09 | 1.04 | 0.86 |
| rs4776471 | 15 | 69,700,119 | RPLP1 (245 kb), TLE3 (348 kb) | T | 1.12 | 0.38 | 0.85 | 0.0 | 1.10 | 0.62 | 1.15 | 0.46 |
| rs11856981 | 15 | 69,743,207 | RPLP1 (288 kb), TLE3 (305 kb) | T | 1.13 | 0.37 | 0.98 | 0.0 | 1.13 | 0.54 | 1.14 | 0.51 |
| rs4288991 | 16 | 52,639,252 | TOX3 (91 kb), CHD9 (416 kb) | C | 0.96 | 0.78 | 0.72 | 0.0 | 1.03 | 0.92 | 0.91 | 0.66 |
| rs8065364 | 17 | 80,189,160 | CARD14 | C | 1.24 | 0.13 | 0.74 | 0.0 | 1.30 | 0.20 | 1.19 | 0.39 |
| rs578211 | 18 | 49,868,025 | MYO5B | A | 0.80 | 0.15 | 0.40 | 0.0 | 0.88 | 0.51 | 0.67 | 0.12 |
| rs4808571 | 19 | 17,115,419 | MYO9B | A | 0.94 | 0.89 | 0.53 | 0.0 | 1.30 | 0.68 | 0.77 | 0.61 |
OR = odds ratio from a random-effects meta-analysis.
P = p-value for OR from a random-effects meta-analysis.
Q = p-value for Cochrane's Q statistic (tests heterogeneity in effects across individual studies).
I2 (I-squared) = heterogeneity index (0–100; 0 = no heterogeneity, 100 = max. heterogeneity).
MAP based on GRCh38 (hg38).
*The gene located nearest to the SNP. Distance to the gene in kilo bases (1,000 bp) is shown in parentheses. If no distance is shown, the SNP is located within the gene locus.