Table I.

Association between clinicopathologic features, VEGF and TP expression levels and MVD.

Clinicopathologic featurea	Cases n=84	VEGF expression			TP expression			MVD
		High (n=53)	Low (n=31)	P-value	High (n=55)	Low (n=29)	P-value	High (n=39)	Low (n=45)	P-value
Gender				0.27			0.15			0.11
Male	55	37	18		33	22		29	26
Female	29	16	13		22	7		10	19
Location				0.77			0.57			0.72
Colon	47	29	18		32	15		21	26
Rectum	37	24	13		23	14		18	19
Histological type				0.25			0.21			0.11
Well	35	24	11		23	12		21	14
Moderate	43	27	16		30	13		16	27
Poor/Other	6	2	4		2	4		2	4
Lymph node metastasis				0.13			0.84			0.15
pN0	36	26	10		24	12		20	16
pN1–4	48	27	21		31	17		19	29
Lymphatic invasion				0.78			0.81			0.63
ly0–1	45	29	16		30	15		22	23
ly2–3	39	24	15		25	14		17	22
Venous invasion				0.57			0.76			0.37
v0–1	62	38	24		40	22		27	35
v2–3	22	15	7		15	7		12	10
Budding				0.88			0.41			0.21
Grade 0–1	47	30	17		29	18		19	28
Grade 2–3	37	23	14		26	11		20	17
Dukes' stage				0.49			0.58			0.047b
A	8	6	2		7	1		7	1
B	26	18	8		16	10		13	13
C	27	14	13		17	10		12	15
D	23	15	8		15	8		7	16

^aClinicopathological feature, according to the TNM classification (3) and the Japanese classification of colorectal carcinoma (7).

^bStatistical significance between stage A and D. VEGF, vascular endothelial growth factor; TP, thymidine phosphorylase; MVD, microvessel density.