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. 2015 Dec 4;13(2):1227–1233. doi: 10.3892/mmr.2015.4636

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Copyright: © Yue et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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4-PBA attenuates ischemia-reperfusion injury in the skin flap of rats. Skin flap tissue sections from rats undergoing ischemia-reperfusion were stained with hematoxylin and eosin (magnification, ×100). Significant swelling and increased numbers of inflammatory cells were detected in the tissue space of the NC group rats; however, these characteristics were absent from the control group, and attenuated in the 4-PBA group rats. Tissue sections were observed 0, 1, 6, 12, and 24 h following ischemia-reperfusion. NC, negative control; 4-PBA, 4-phenylbutyrate.