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. 2015 Dec 30;13(2):1577–1585. doi: 10.3892/mmr.2015.4750

Figure 6.

Figure 6

Hypoxia-induced [Ca2+]i elevation in PVSMCs is independent of PLC. (A) Effects of 10 µM U73122, an antagonist of PLC, on changes in [Ca2+]i (Δ[Ca2+]i) under hypoxic conditions (4% O2; black; n=3 experiments in 72 cells). (B) Effects of 40 µM compound C, an antagonist of AMPK, on Δ[Ca2+]i under hypoxic conditions (4% O2; brown, n=3 experiments in 76 cells). (C) PLC and AMPK inhibition of Δ[Ca2+]i under hypoxic conditions. Data are presented as the mean ± standard error of the mean (*P<0.05). [Ca2+]i, intracellular Ca2+ concentration; PVMSC, pulmonary vein smooth muscle cell; PLC, phospholipase C; AMPK, AMP-activated protein kinase.