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. 2015 Dec 14;13(2):1156–1162. doi: 10.3892/mmr.2015.4686

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Losartan decreased intestinal permeability by inhibiting intestinal epithelial cell (IEC) apoptosis. (A) Representative terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining of each treatment group on day 2 after TNBS treatment. Red spots indicate TUNEL-positive apoptotic IECs. (B) Apoptotic index in each group. Apoptotic index was defined as the percentage of TUNEL-positive cells in 100 randomly selected IECs (n=5/group). ^#P>0.05, ^**P<0.01 and ^***P<0.001. (C) Measurement of intestinal permeability (n=5/group). ^#P>0.05, ^*P<0.05, ^**P<0.01 and ^***P<0.001. TNBS, 2,4,6-trinitro-benzenesulphonic acid; EtOH, ethanol; FITC, fluorescein isothiocyanate.