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. 2015 Dec 23;13(2):1586–1592. doi: 10.3892/mmr.2015.4712

Figure 2.

Figure 2

Cholesterol treatment attenuates ketamine-induced neuroapoptosis detected. (A) TUNEL labeling was performed to visualize the extent of apoptosis. TUNEL-positive cells indicate cellular apoptosis. Arrows in all panels indicate neurons with apoptotic morphology (magnification, ×400). (Aa) Control; (Ab) 5 µM cholesterol treatment; (Ac) 100 µM ketamine treatment; (Ad) 100 µM ketamine + 5 µM cholesterol treatment. (B) Quantification of the percentage of apoptotic cells present following different treatments. Data are presented as the mean ± standard deviation (n=3). **P<0.01 vs. the control group, ##P<0.01 vs. the ketamine-treated group and +P<0.05 vs. the cholesterol-treated group. TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.